姓名 | 吴轶群 |
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职称 | 教授 | |
导师资格 | 博士生导师 | |
学科专业 | 口腔医学 | |
联系方式 | 电话：13916892306 E-mail：yiqunwu@hotmail.com | |
一、个人简介 医学博士，主任医师，博士生导师，上海交通大学医学院附属第九人民医院口腔第二门诊部主任。现任中华口腔医学会口腔种植专业委员会副主任委员，国际口腔种植协会专家组成员。担任十三五国家重点研发项目课题负责人，主持国家自然科学基金、上海交通大学医工（理）交叉基金重点项目、国际口腔种植协会（ITI）资助项目等多项国家级、国际级课题项目，研究成果曾获国家科技进步二等奖（2019）、中华口腔医学科技三等奖（2018）、华夏医学奖三等奖（2016），上海市科技进步一等奖（2010）等。高新科技成果转化1项（2019），获得国家专利证书12项。发表论文40余篇，参编著作10部，主译著作1部。担任《中国口腔种植学杂志》副主编，《口腔疾病防治》、《上海口腔医学》、《口腔材料器械杂志》编委。 | ||
二、主要学习与工作经历 教育背景： 1988年9月－1993年6月上海第二医科大学、口腔医学 学士 1996年9月－1999年6月上海第二医科大学、口腔医学 硕士 2002年9月－2005年6月上海交通大学、口腔医学 博士 工作经历： 1993年7月－1996年8月 太原市中心医院口腔科 住院医师 1999年7月－2001年10月上海第九人民医院口腔种植科 住院医师 2001年11月—2005年11月上海第九人民医院口腔种植科 主治医师 2005年11月—2013年11月上海第九人民医院口腔种植科 副主任医师 2013年11月—2016年5月上海第九人民医院口腔种植科 主任医师 2016年5月—2017年12月上海第九人民医院口腔第二门诊部 主任医师（副主任） 2018年1月—至今 上海第九人民医院口腔第二门诊部 主任医师（科主任） | ||
三、主要科研工作与成绩
代表性论文
1、Wang F, Tao B, Shen Y, Li C, Huang W, Sun Y, Wu Y. A single-arm clinical trial investigating the feasibility of the zygomatic implant quad approach for Cawood and Howell Class 4 edentulous maxilla: An option for immediate loading. Clin Implant Dent Relat Res. 2021 Oct;23(5):800-808. (corresponding author) 2、Wu Y, Wang F. Guided and Navigation Techniques for Zygomatic Implants. Atlas Oral Maxillofac Surg Clin North Am. 2021 Sep;29(2):253-269. 3、Wang T, Ye L, Sun Y, Wu Y. Fabricating a surgical template for guiding sinus floor elevation in the maxillary sinus septa with simultaneous implant placement: A dental technique. J Prosthet Dent. 2021 Sep 4:S0022-3913(21)00404-2.(corresponding author) 4、Yu K, Shen Y, Jiang C, Huang W, Wang F, Wu Y. Two novel ectodysplasin A gene mutations and prenatal diagnosis of X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2021 Sep 28:e1824. Epub ahead of print. (corresponding author) 5、Zhou W, Wang F, Magic M, Zhuang M, Sun J, Wu Y. The effect of anatomy on osteogenesis after maxillary sinus floor augmentation: a radiographic and histological analysis. Clin Oral Investig. 2021 Sep;25(9):5197-5204. (corresponding author) 6、Zhou M, Zhang H, Camhi H, Seymen F, Koruyucu M, Kasimoglu Y, Kim JW, Kim-Berman H, Yuson NMR, Benke PJ, Wu Y, Wang F, Zhu Y, Simmer JP, Hu JC. Analyses of oligodontia phenotypes and genetic etiologies. Int J Oral Sci. 2021 Sep 30;13(1):32. 7、Gao Y, Qin C, Tao B, Hu J, Wu Y, Chen X. An electromagnetic tracking implantation navigation system in dentistry with virtual calibration. Int J Med Robot. 2021 Apr;17(2):e2215. 8、Jiang X, Zhou W, Wu Y, Wang F. Clinical outcomes of immediate implant loading with fixed prostheses in edentulous maxillae: a systematic review. Int J Oral Maxillofac Implants. 2021 May-Jun;36(3):503-519 9、Lan K, Wang F, Huang W, Davó R, Wu Y. Quad Zygomatic Implants: A Systematic Review and Meta-analysis on Survival and Complications. Int J Oral Maxillofac Implants. 2021 Jan-Feb;36(1):21-29. (corresponding author) 10、Magic M, Wang F, Fan S, Wu Y. Dynamic Navigation Guidance for Bone Reduction in Maxilla: Case Report. Int J Oral Maxillofac Implants. 2021 Jan-Feb;36(1):Ie1-e6. (corresponding author) 11、Cao J, Zhou W, Shen S, Wu Y, Wang X. Implant-supported provisional prosthesis facilitated the minor revision of occlusion and incisor exposure after orthognathic surgery of extended oligodontia in maxilla. J Dent Sci. 2021 Jan;16(1):544-548. 12、Tao B, Shen Y, Sun Y, Huang W, Wang F, Wu Y. Comparative accuracy of cone-beam CT and conventional multislice computed tomography for real-time navigation in zygomatic implant surgery. Clin Implant Dent Relat Res. 2020 Dec;22(6):747-755. (corresponding author) 13、Li Y, Hu J, Tao B, Yu D, Shen Y, Fan S, Wu Y, Chen X. Automatic robot-world calibration in an optical-navigated surgical robot system and its application for oral implant placement. Int J Comput Assist Radiol Surg. 2020 Oct;15(10):1685-1692. 14、Zhou W, Fan S, Wang F, Huang W, Jamjoom F, Wu Y. A novel extraoral registration method for a dynamic navigation system guiding zygomatic implant placement in patients with maxillectomy defects. Int. J. Oral Maxillofac. Surg. 2020 Jun 2;S0901-5027(20)30126-0. (corresponding author) 15、Yu D, Liu C, Wu Y, An Q. Measurement and prediction of drilling force in fresh human cadaver mandibles: A pilot study. Clin Implant Dent Relat Res. 2020 Feb;22(1):4-12. 16、Cao Z, Qin C, Fan S, Yu D, Wu Y, Qin J, Chen X. Pilot study of a surgical robot system for zygomatic implant placement. Med Eng Phys. 2020 Jan;75:72-78. 17、Wu Y, Wang F, Fan S, Chow JK. Robotics in Dental Implantology. Oral Maxillofac Surg Clin North Am. 2019 Aug;31(3):513-518. 18、Wu Y, Wang F, Huang W, Fan S. Real-Time Navigation in Zygomatic Implant Placement: Workflow. Oral Maxillofac Surg Clin North Am. 2019 Aug;31(3):357-367. 19、Zhao K, Yu K, Wang F, Sun Y, Wu Y. Mutation screening and functional analysis for 8 patients with ectodermal dysplasia. Shanghai Kou Qiang Yi Xue. 2019 Jun;28(3):268-274. Chinese.(corresponding author) 20、Zhao K, Lian M, Zou D, Huang W, Zhou W, Shen Y, Wang F, Wu Y. Novel mutations identified in patients with tooth agenesis by whole-exome sequencing. Oral Dis. 2019 Mar;25(2):523-534. (corresponding author) 21、Fan S, Hung K, Bornstein MM, Huang W, Wang F, Wu Y. The effect of the configurations of fiducial markers on accuracy of surgical navigation in zygomatic implant placement: An in vitro study. Int J Oral Maxillofac Implants. 2019 January/February;34(1):85–90. (corresponding author) 22、Qin C, Cao Z, Fan S, Wu Y, Sun Y, Politis C, Wang C, Chen X. An oral and maxillofacial navigation system for implant placement with automatic identification of fiducial points. Int J Comput Assist Radiol Surg. 2019 Feb;14(2):281-289. 23、Wang F, Zhou Y, Zhou J, Xu M, Zheng W, Huang W, Zhou W, Shen Y, Zhao K, Wu Y, Zou D. Comparison of Intraoral Bone Regeneration with Iliac and Alveolar BMSCs. Journal of Dental Research 2018, Vol. 97(11) 1229–1235.(corresponding author) 24、Zhao K, Lian M, Fan S, Huang W, Wang F, Wu Y. Long-term Schneiderian membrane thickness changes following zygomatic implant placement: A retrospective radiographic analysis using cone beam computed tomography. Clin Oral Implants Res. 2018 Jul;29(7):679-687. (corresponding author) 25、Zhao K, Wang F, Huang W, Wu Y. Clinical Outcomes of Vertical Distraction Osteogenesis for Dental Implantation: A Systematic Review and Meta-Analysis. Int J Oral Maxillofac Implants. 2018 May/Jun;33(3):549-564. (corresponding author) 26、Bo F, Gu W, Ling X, Wu Y, Wang Y. Perioperative nursing of zygomatic implant surgery for patients with severe periodontitis. Shanghai Kou Qiang Yi Xue. 2018 Feb;27(1):106-109. Chinese. 27、Wang F, Bornstein MM, Hung K, Fan S, Chen X, Huang W, Wu Y. Application of Real-Time Surgical Navigation for Zygomatic Implant Insertion in Patients With Severely Atrophic Maxilla. J Oral Maxillofac Surg. 2018 Jan;76(1):80-87. (corresponding author) 28、Wang H, Wang F, Huang W, Zhou W, Wang Y, Wu Y. Morphometric analysis of maxillofacial bone in 48 patients with ectodermal dysplasia. Shanghai Kou Qiang Yi Xue. 2017 Apr;26(2):193-197. Chinese. (corresponding author) 29、Wang F, Huang W, Wu Y, Montanero-Fernandez J, Sheridan RA, Wang HL, Monje A. Accuracy of Cone Beam Computed Tomography Grayscale Density in Determining Bone Architecture in the Posterior Mandible: An In Vivo Study with Microcomputed Tomography Validation. Int J Oral Maxillofac Implants. 2017;32(5):1074-1079. 30、Hung K, Ai Q, Fan S, Wang F, Huang W, Wu Y. Measurement of the zygomatic region for the optimal placement of quad zygomatic implants. Clin Implant Dent Relat Res. 2017 Aug 1. [Epub ahead of print] (corresponding author) 31、Zhao K, Wang F, Huang W, Wu Y. Comparison of dental implant performance following vertical alveolar bone augmentation with alveolar distraction osteogenesis or autogenous onlay bone grafts: a retrospective cohort study. J Oral Maxillofac Surg. 2017 Oct;75(10):2099-2114. (corresponding author) 32、Hung K, Wang F, Wang H, Zhou W, Huang W, Wu Y. Accuracy of a real-time surgical navigation system for the placement of quad zygomatic implants in the severe atrophic maxilla: A pilot clinical study. Clin Implant Dent Relat Res. 2017 Jun;19(3):458-465. (corresponding author) 33、Wang F, Huang W, Zhang Z, Wang H, Monje A, Wu Y. Minimally invasive flapless vs. flapped approach for single implant placement: a 2-year randomized controlled clinical trial. Clin Oral Implants Res. 2017 Jun;28(6):757-764. (corresponding author) 34、Monje A, Wu Y, Huang W, Zhou W, Galindo-Moreno P, Montanero-Fernandez J, Sheridan RA, Wang HL, Wang F. Influence of Posterior Mandibular Dimensions on Alveolar Bone Microarchitecture. Int J Oral Maxillofac Implants. 2017 Mar/Apr;32(2):423–430. 35、Wang F, Zhou W, Monje A, Huang W, Wang Y, Wu Y. Influence of Healing Period Upon Bone Turn Over on Maxillary Sinus Floor Augmentation Grafted Solely with Deproteinized Bovine Bone Mineral: A Prospective Human Histological and Clinical Trial. Clin Implant Dent Relat Res. 2017 Apr;19(2):341-350. (corresponding author) 36、Wang F, Huang W, Zhang C, Sun J, Qu X, Wu Y. Functional outcome and quality of life after a maxillectomy: a comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap. Clin Oral Implants Res. 2017 Feb;28(2):137-143. (corresponding author) 37、Wu Y, Huang W, Zhang Z, Zhang Z, Zou D. Long-term success of dental implant-supported dentures in postirradiated patients treated for neoplasms of the maxillofacial skeleton: a retrospective study. Clin Oral Investig. 2016 Dec;20(9):2457-2465. 38、Hung K, Huang W, Wang F, Wu Y. Real-Time Surgical Navigation System for the Placement of Zygomatic Implants with Severe Bone Deficiency.Int J Oral Maxillofac Implants. 2016 Nov/Dec;31(6):1444-1449. (corresponding author) 39、Zhou W, Wang F, Monje A, Elnayef B, Huang W, Wu Y. Feasibility of Dental Implant Replacement in Failed Sites: A Systematic Review. International Journal of Oral & Maxillofacial Implants. 2016, 31(3):535-545. (corresponding author) 40、Wang F, Monje A, Lin G, Wu Y, Monje F, Wang H, Davó R. Reliability of four zygomatic implant-supported prostheses for the rehabilitation of the atrophic maxilla: a systematic review. Int J Oral Maxillofac Implants. 2015 Mar-Apr;30(2):293-298. 41、Wang F, Monje A, Zhang Z, Huang W, Wang G, Wu Y. Maxillary Four Implant-retained Overdentures via Locator® Attachment: Intermediate-term Results. Clin Implant Dent Relate Res. 2015 Mar 23. (corresponding author) 42、Wu Y，Wang F, Shen Y, Lin M. Eye-Lid approach for four zygomatic implant placement in the severely reabsorbed maxillae: technical note. Int J Clin Exp Med. 2015 Mar 15;8(3):4670-4675. 43、Wu Y，Wang XD，Wang F，Huang W，Zhang Z，Zhang Z，Kaigler D，Zou D. Restoration of Oral Function for Adult Edentulous Patients with Ectodermal Dysplasia: A Prospective Preliminary Clinical Study. Clin Implant Dent Relat Res. 2015;17(2): e633-42. 44、Wu Y，Zhang C，Squarize CH，Zou D. Oral Rehabilitation of Adult Edentulous Siblings Severely Lacking Alveolar Bone Due to Ectodermal Dysplasia: A Report of 2 Clinical Cases and a Literature Review. J Oral Maxillofac Surg. 2015;73(9): 1733.e1-12 . 45、Wang F，Zhang Z，Monje A，Huang W，Wu Y，Wang G. Intermediate long-term clinical performance of dental implants placed in sites with a previous early implant failure: a retrospective analysis. Clinical Oral Implants Research. 2015;26(12):1443-1449. 46、Zou D，Huang W，Wang F，Wang S，Zhang Z，Zhang C，Kaigler D，Wu Y. Autologous Ilium Grafts: Long-Term Results on Immediate or Staged Functional Rehabilitation of Mandibular Segmental Defects Using Dental Implants after Tumor Resection. Clin Implant Dent Relat Res 2015;17(4):779-789. (corresponding author) 47、Zou D，Wang F，Wu Y，Huang W，Zhang C，Zhang Z. Implant-Supported Telescopic Crown-Retained Overdentures for Oral Rehabilitation of Patients with Severe Bony Defects: A 5-Year Retrospective Study. Int J Oral Maxillofac Implants 2015;30(4):937-944. 48、Wang F, Wu Y, Zou D, Wang G, Kaigler D. Clinical outcomes of dental implant therapy in alveolar cleft patients: a systematic review. Int J Oral Maxillofac Implants. 2014 Sep-Oct;29(5):1098-1105. 49、Huang W，Wu Y，Zou D，Zhang Z，Zhang C，Sun J，Xu B，Zhang Z. Long-Term Results for Maxillary Rehabilitation with Dental Implants after Tumor Resection. Clin Implant Dent Relat Res. 2014;16(2):282-291. 50、Zou D，Wu Y，Huang W，Wang F，Wang S，Zhang Z，Zhang Z，A 3-year prospective clinical study of telescopic crown, bar, and locator attachments for removable four implant-supported maxillary overdentures. Int J Prosthodont. 2013;26(6):566-573. 51、Wang F，Wu Y，Zhang C，Zhang Zh. Dental implant performance in vertically distracted fibular grafts after mandibular reconstruction: a pilot series of 12 patients. Int J Oral Maxillofac Implants 2013;28(5):1311-1321. 52、Zou D，Wu Y，Huang W，Zhang Z，Zhang Z. A 5- to 8-year retrospective study comparing the clinical results of implant-supported telescopic crown versus bar overdentures in patients with edentulous maxillae. Int J Oral Maxillofac Implants 2013;28(5):1322-1330. 53、Zhang C, Min R, Xu L, Hu Y, Yang W, Ji T, Qu X, Siyi L, Ow A, Jizhuang M, Wu Y. Dental implant distractor combined with free fibular flap: a new design for simultaneous functional mandibular reconstruction. J Oral Maxillofac Surg. 2012;70(11): 2687-2700. 54、Chen X, Wu Y, Wang C. Application of a surgical navigation system in the rehabilitation of maxillary defects using zygoma implants: report of one case. Int J Oral Maxillofac Implants. 2011;26(5):e29-34. 55、He Y, Zhang Z, Zhu H, Wu Y, Fu H. Double-barrel fibula vascularized free flap with dental rehabilitation for mandibular reconstruction. J Oral Maxillofac Surg. 2011;69(10):2663-2669. 56、Chen X, Ming Y, Liu Y, Wu Y, Wu C. Image guided oral implantology and its application in the placement of zygoma implants. Comput Methods Programs Biomed. 2009;93(2): 162-173. 57、Chen X, Lin Y, Wu Y, Wang C. Real-time motion tracking in image-guided oral implantology. Int J Med Robot. 2008;4(4): 339-347. 58、Wu Y, Huang W, Zhang Z, Zhang Z, Zhang C, Sun J. Clinical outcome of dental implants placed in fibula-free flaps for orofacial reconstruction. Chin Med J (Engl). 2008;121(19):1861-1865 59、Zhang Z, Huang W, Lai H, Wu Y, Wang F, Wang S. 7-year clinical application of Straumann implants. Shanghai Kou Qiang Yi Xue. 2008 Jun;17(3):267-71. Chinese. 60、Wu Y, Zhang Z, Tie Y, Zhang Z, Wang D, Zhang C, Wang C. Biomechanical evaluation of zygomatic implant in unilateral maxillary defect restorationShanghai Kou Qiang Yi Xue. 2008 Jun;17(3):250-5. Chinese. 61、Chen X, Lin Y, Wu Y, Wang C. Research on the development of image guided oral implant system.Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Apr;25(2):429-34, 438. Chinese. 62、Xu YL, Fang B, Mao LX, Feng YM, Xia YH, Lou XT, Wu Y. Cephalometric analysis of implant anchorage-assisted retraction of anterior teeth.Shanghai Kou Qiang Yi Xue. 2008 Feb;17(1):20-4. Chinese. 63、Lai H, Xu Y, Zhang Z, Huang W, Wu Y. Buccal soft tissue augmentation using acellular dermal matrix in implant therapy.Zhonghua Kou Qiang Yi Xue Za Zhi. 2006 Jul;41(7):395-6. Chinese. 64、Wu Y, Zhang Z, Zhang C, Huang W, Sun J, Zhang Z.The installation of zygomatic implants and drilling guide.Zhonghua Kou Qiang Yi Xue Za Zhi. 2006 Mar;41(3):140-3. Chinese. 65、Hu Y, Li S, Zhang Z, Xu L, Qu X, Hardianto A, Wu Y, Zhang C. Combined vascularized iliac osteo-musculo-cutaneous flap with zygomatic implant anchorage in reconstructing 1 case of maxillary defect.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005 Oct;19(10):807-10. Chinese. 66、Wu Y, Zhang Z, Zhang Z, Sun J, Huang W, Hu Y, Zhang C. Zygomatic implants anchorage for the rehabilitation of maxillary defects.Shanghai Kou Qiang Yi Xue. 2005 Jun;14(3):210-4. Chinese. 67、Wu Y, Zhang Z, Zhang Z, Huang W, Lai H, Hu Y, Zhang C. ITI dental implants immediately placed into vascularized iliac bone grafts for reconstruction of mandibular defect: analysis of 12 consecutive cases.Shanghai Kou Qiang Yi Xue. 2005 Apr;14(2):103-7. Chinese. 68、Tie Y, Wang D, Wang C, Wu Y, Zhang Z. Biomechanical evaluation of unilateral maxillary defect restoration based on modularized finite element model of normal human skull. Conf Proc IEEE Eng Med Biol Soc. 2005;6:6184-7. 69、Zhang Z, Huang W, Yu Q, Fan X, Wu Y. Application of CT scanning in presurgical planning of dental implants.Shanghai Kou Qiang Yi Xue. 2002 Mar;11(1):86-7. Chinese.
代表性项目、课题
1、miR-210介导的牙周膜干细胞修复标准骨缺损及ERK/P38信号转导通路的调控机制（69万）2014/1-2017/12 2、颌骨重度萎缩与缺损患者的口腔功能重建（150万）2017/9-2020/9 3、面向狭窄空间精准颧种植手术的机器人机构设计及实时导航关键技术研究（75万）2017/1-2019/12 4、口腔种植机器人手术终端系统的研发、评估及SOP制定（385万） 2017/12-2020/11 5、学科-融合-口腔二部2（100万）2017/8-2018/7 6、学科-融合-口腔二部3（80万）2018/11-2019/10 7、口腔种植专用手术机器人研发及评价改进研究（346万） 2018年 8、预研基金吴轶群-ky2018190150（2.4万）2018/7-2020/5 9、预研基金吴轶群-ky2018190151（1.9万）2018/7-2020/5 10、颧种植手术上颌窦粘膜保护微创套装的研发（8万）2019/12-2021/11 11、专科联盟发展基金-口腔第二门诊（15万）2020/5-2021/8 12、口腔种植外科导航系统研发及临床前评价（150万） 2020/10-2022/9 13、仿生磷酸钙生物骨作为拔牙位点保存骨填充材料的有效性和安全性的探索性临床试验（70万） 2020/8-2022/7- 14、外胚层发育不良相关颌骨骨代谢异常的机制研究（20万）2021/7-2024/6 15、先天性牙缺失生物样本库的建立（20万）2021/8-2024/8 16、Accuracy of dynamic navigation vs.surgical template for implant placement in partially edentulous patients:Arandomized clinical trial (5万美金）2020/8-2022/7 17、Schneiderian membrane thickness changes following zygomatic implant(Straumannzygomatic implant) placement: a prospective, single arm clinical trial (30万）2021 | ||
四、主要社会学术团体兼职 中华口腔医学会口腔种植专业委员会副主任委员 国际口腔种植协会专家委员会委员（ITI Fellow） 国际口腔种植协会中国分会国际教育部主任 国际口腔种植协会上海奖学金中心主任（ITI Scholarship Centre） 上海九院-爱丁堡皇家外科学院口腔种植与修复培训考试中心主任 上海市口腔医学会理事 上海口腔医学会口腔种植专业委员会常务委员 | ||
五、主要研究方向 研究领域为无牙颌种植，长期从事口腔及颅颌面种植的临床和基础研究工作，尤其对牙槽脊骨量严重不足、肿瘤性颌骨严重缺失、数字化导板、计算机辅助导航系统的种植修复进行深入研究。在国内率先开展在静态导板及动态实时导航模式下颧种植体植入及重度颌骨萎缩、严重颌骨缺损患者口腔功能重建，构建数字化口腔种植平台，发起动态导航软件开发及应用。国际上首次提出外胚层发育不全患者无牙颌口腔功能重建的“综合序列治疗方案”。 | ||
六、全日制专业学位联合培养单位 上海交通大学医学院附属第九人民医院 | ||
