三、主要科研工作与成绩 （一）代表性论文：一区9篇 Sessler DI, Pei L, Li K, Cui S, Chan MTV, Huang Y, Wu J, He X, Bajracharya GR, Rivas E, Lam CKM, Investigators P. Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial. Lancet. 2022;399(10337):1799-808.（IF=202，中科院一区） Huang C, Huang Q, Shen Y, Liu K, Wu J*. General anaesthesia with double-lumen intubation compared to opioid-sparing strategies with laryngeal mask for thoracoscopic surgery: A randomised trial. Anaesth Crit Care Pain Med. 2022;41(3):101083.（IF=7.025，JCR一区） Tong C, Shen Y, Zhu H, Zheng J, Xu Y, Wu J*. Continuous Relationship of Operative Duration with Risk of Adverse Perioperative Outcomes and Early Discharge Undergoing Thoracoscopic Lung Cancer Surgery. Cancers. 2023;15(2).（IF=6.575，JCR一区） Li X, Wang W, Zhang X, Gong Z, Tian M, Zhang Y, You X, Wu J*. Neuroinflammation in the medial prefrontal cortex exerts a crucial role in bone cancer pain. Front Mol Neurosci. 2022;15:1026593.（IF=6.261，JCR一区） Zhang X, Li X, Wang W, Zhang Y, Gong Z, Peng Y, Wu J*, You X*: STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex. Cancers (Basel) 2022; 14（IF=6.575，JCR一区） Wu J, Li X, Zhang X, Wang W, You X. What role of the cGAS-STING pathway plays in chronic pain? Front Mol Neurosci. 2022;15:963206. （IF=6.261，JCR一区） Zhang Y, Liu X, Geng C, Shen H, Zhang Q, Miao Y, Wu J*, Ouyang R*, Zhou S*: Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration. Nanomaterials (Basel) 2023; 13 （IF=5.719，JCR一区） Tong C, Zheng J, Wu J*: The effects of paravertebral blockade usage on pulmonary complications, atrial fibrillation and length of hospital stay following thoracoscopic lung cancer surgery. J Clin Anesth 2022; 79: 110770 （IF=9.375，JCR一区） Zhang Z, Xu M, Wu D, Zhang X, Wu J*: Postoperative Myocardial Injury in Middle-Aged and Elderly Patients Following Curative Resection of Esophageal Cancer With Aggressive or Standard Body Temperature Management: A Randomized Controlled Trial. Anesth Analg 2019; 129: 352-359（IF=6.627，JCR一区）
（二）代表性课题： 国家自然科学基金委员会, 面上项目, 82071233, 破骨细胞分泌Netrin-1促进骨感觉神经突起生长参与骨癌痛的机制研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 主持 国家自然科学基金委员会, 面上项目, 81671078, 骨形态发生蛋白信号系统在骨癌痛大鼠外周痛觉敏化机制中的作用, 2017-01-01 至 2020-12-31, 52万元, 结题, 主持 学院, 医工交叉重点项目, 2022-1-20, 一种用于治疗骨癌痛的铋基光热靶向给药设备的研发, 2022-09 至 2024-09, 20万元, 在研, 主持 上海申康医院发展中心, 促进市级医院临床技能与临床创新 三年行动计划（2020-2022年） 重大临床研究项目, SHDC2020CR4063, 中老年患者肺癌切除术中个体化保护性通气策略减少术后肺部并发症的前瞻性随机对照研究, 2020-10 至 2022-09, 50万元, 在研, 主持 上海市科学技术委员会, 医学引导类（西医）科技支撑项目, 16411967600, 围术期体温保护策略降低中老年胸科手 术患者心肌损伤相关不良事件的研究, 2016-06 至 2019-09, 20万元, 结题, 主持
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